Homocysteine and risk of open-angle glaucoma

S Bleich; A Jünemann; N von Ahsen; B Lausen; K Ritter; G Beck; G O H Naumann; J Kornhuber

doi:10.1007/s007020200097

Homocysteine and risk of open-angle glaucoma

J Neural Transm (Vienna). 2002 Dec;109(12):1499-504. doi: 10.1007/s007020200097.

Authors

S Bleich¹, A Jünemann, N von Ahsen, B Lausen, K Ritter, G Beck, G O H Naumann, J Kornhuber

Affiliation

¹ Department of Psychiatry and Psychotherapy, Friedrich-Alexander-University, Schwabachanlage 6-10, D-91054 Erlangen-Nuremberg, Federal Republic of Germany. stefan.bleich@psych.imed.uni-erlangen.de

PMID: 12486490
DOI: 10.1007/s007020200097

Abstract

Homocysteine levels and the frequency of heterozygous methylenetetrahydrofolate reductase (MTHFR) C677T mutation are increased in open-angle glaucoma. Since homocysteine can induce vascular injury, alterations in extracellular matrix remodelling, and neuronal cell death, these findings may have important implications for understanding glaucomatous optic neuropathy.

MeSH terms

Adult
Aged
Aged, 80 and over
Case-Control Studies
Female
Glaucoma, Open-Angle / blood*
Glaucoma, Open-Angle / genetics*
Homocysteine / blood*
Humans
Male
Methylenetetrahydrofolate Reductase (NADPH2)
Middle Aged
Oxidoreductases Acting on CH-NH Group Donors / genetics*
Polymorphism, Genetic
Prospective Studies

Substances

Homocysteine
Oxidoreductases Acting on CH-NH Group Donors
Methylenetetrahydrofolate Reductase (NADPH2)