Mechanisms of cellular iron acquisition: another iron in the fire

Cell. 2002 Nov 27;111(5):603-6. doi: 10.1016/s0092-8674(02)01164-9.

Abstract

Iron transport occurs by the well-known transferrin (Tf)-transferrin receptor (Tf receptor) system and by a second as yet uncharacterized system. Two reports in the current issue of Molecular Cell suggest an unexpected candidate for the Tf-independent system.

Publication types

  • Review

MeSH terms

  • Acute-Phase Proteins / metabolism
  • Animals
  • Antimicrobial Cationic Peptides / metabolism
  • Biological Transport
  • Cation Transport Proteins / metabolism
  • Endosomes / metabolism
  • Hepcidins
  • Humans
  • Intestinal Mucosa / metabolism
  • Iron / metabolism*
  • Iron-Binding Proteins / metabolism
  • Lactoferrin / metabolism
  • Lipocalin-2
  • Lipocalins
  • Models, Biological
  • Oncogene Proteins / metabolism
  • Proto-Oncogene Proteins
  • Receptors, Transferrin / metabolism
  • Siderophores / metabolism
  • Transferrin / metabolism

Substances

  • Acute-Phase Proteins
  • Antimicrobial Cationic Peptides
  • Cation Transport Proteins
  • Hepcidins
  • Iron-Binding Proteins
  • LCN2 protein, human
  • Lipocalin-2
  • Lipocalins
  • Oncogene Proteins
  • Proto-Oncogene Proteins
  • Receptors, Transferrin
  • Siderophores
  • Transferrin
  • metal transporting protein 1
  • solute carrier family 11- (proton-coupled divalent metal ion transporters), member 2
  • Iron
  • Lactoferrin