Overlapping and specific patterns of GDNF, c-ret and GFR alpha mRNA expression in the developing chicken retina

Mech Dev. 2002 Jun;114(1-2):161-5. doi: 10.1016/s0925-4773(02)00045-x.

Abstract

GDNF and the GDNF receptors, c-Ret, GFR alpha 1 and 2 mRNA is expressed in the developing chicken retina. GDNF labelling was mainly found in embryonic day 4-5 retina but weak labelling could also be found over scattered retinal cells at later stages. c-ret labelling was found over ganglion cells, amacrine and horizontal cells; the preferred GDNF receptor (GFR alpha 1) over amacrine and horizontal cells; and the less preferred GDNF receptor (GFR alpha 2) over ganglion cells, amacrine cells and photoreceptors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chick Embryo
  • Dose-Response Relationship, Drug
  • Drosophila Proteins*
  • Glial Cell Line-Derived Neurotrophic Factor
  • Glial Cell Line-Derived Neurotrophic Factor Receptors
  • In Situ Hybridization
  • Nerve Growth Factors / biosynthesis*
  • Nerve Growth Factors / pharmacology
  • Neurons / metabolism
  • Neurturin
  • Photoreceptor Cells / embryology
  • Protein Structure, Tertiary
  • Proto-Oncogene Proteins / biosynthesis*
  • Proto-Oncogene Proteins / genetics
  • Proto-Oncogene Proteins c-ret
  • RNA, Messenger / metabolism
  • Receptor Protein-Tyrosine Kinases / biosynthesis*
  • Receptor Protein-Tyrosine Kinases / genetics
  • Retina / embryology*
  • Signal Transduction
  • Time Factors

Substances

  • Drosophila Proteins
  • Glial Cell Line-Derived Neurotrophic Factor
  • Glial Cell Line-Derived Neurotrophic Factor Receptors
  • Nerve Growth Factors
  • Neurturin
  • Proto-Oncogene Proteins
  • RNA, Messenger
  • Proto-Oncogene Proteins c-ret
  • Receptor Protein-Tyrosine Kinases
  • Ret protein, Drosophila