Abstract
GDNF and the GDNF receptors, c-Ret, GFR alpha 1 and 2 mRNA is expressed in the developing chicken retina. GDNF labelling was mainly found in embryonic day 4-5 retina but weak labelling could also be found over scattered retinal cells at later stages. c-ret labelling was found over ganglion cells, amacrine and horizontal cells; the preferred GDNF receptor (GFR alpha 1) over amacrine and horizontal cells; and the less preferred GDNF receptor (GFR alpha 2) over ganglion cells, amacrine cells and photoreceptors.
Copyright 2002 Elsevier Science Ireland Ltd.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Chick Embryo
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Dose-Response Relationship, Drug
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Drosophila Proteins*
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Glial Cell Line-Derived Neurotrophic Factor
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Glial Cell Line-Derived Neurotrophic Factor Receptors
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In Situ Hybridization
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Nerve Growth Factors / biosynthesis*
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Nerve Growth Factors / pharmacology
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Neurons / metabolism
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Neurturin
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Photoreceptor Cells / embryology
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Protein Structure, Tertiary
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Proto-Oncogene Proteins / biosynthesis*
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Proto-Oncogene Proteins / genetics
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Proto-Oncogene Proteins c-ret
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RNA, Messenger / metabolism
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Receptor Protein-Tyrosine Kinases / biosynthesis*
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Receptor Protein-Tyrosine Kinases / genetics
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Retina / embryology*
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Signal Transduction
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Time Factors
Substances
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Drosophila Proteins
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Glial Cell Line-Derived Neurotrophic Factor
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Glial Cell Line-Derived Neurotrophic Factor Receptors
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Nerve Growth Factors
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Neurturin
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Proto-Oncogene Proteins
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RNA, Messenger
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Proto-Oncogene Proteins c-ret
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Receptor Protein-Tyrosine Kinases
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Ret protein, Drosophila