Abstract
Key events in mitosis such as sister chromatid separation and subsequent inactivation of cyclin-dependent kinase 1 are regulated by ubiquitin-dependent proteolysis. These events are mediated by the anaphase-promoting complex (APC), a cell cycle-regulated ubiquitin ligase that assembles multiubiquitin chains on regulatory proteins such as securin and cyclins and thereby targets them for destruction by the 26S proteasome.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Anaphase-Promoting Complex-Cyclosome
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Animals
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Cell Cycle Proteins / metabolism
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Cyclins / physiology
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Endopeptidases*
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Ligases / physiology*
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Mitosis / physiology*
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Peptide Hydrolases / metabolism
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Proteasome Endopeptidase Complex*
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Separase
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Signal Transduction
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Transforming Growth Factor beta / physiology
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Ubiquitin-Protein Ligase Complexes*
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Ubiquitins / metabolism
Substances
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Cell Cycle Proteins
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Cyclins
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Transforming Growth Factor beta
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Ubiquitins
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Ubiquitin-Protein Ligase Complexes
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Anaphase-Promoting Complex-Cyclosome
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Endopeptidases
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Peptide Hydrolases
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Separase
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Proteasome Endopeptidase Complex
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ATP dependent 26S protease
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Ligases