Signal transduction and the control of gene expression

Science. 2002 Feb 1;295(5556):813-8. doi: 10.1126/science.1066355.

Abstract

More than 2000 transcription factors are encoded in the human genome. Such proteins have often been classified according to common structural elements. But because transcription factors evolved in the service of biologic function, we propose an alternative grouping of eukaryotic transcription factors on the basis of characteristics that describe their roles within cellular regulatory circuits.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Nucleus / metabolism
  • Cytoplasm / metabolism
  • DNA / metabolism
  • DNA-Binding Proteins / metabolism
  • Gene Expression Regulation*
  • Phosphorylation
  • Phosphoserine / metabolism
  • Receptors, Cell Surface / metabolism
  • Second Messenger Systems
  • Signal Transduction*
  • Transcription Factors / chemistry
  • Transcription Factors / classification*
  • Transcription Factors / metabolism*
  • Transcription, Genetic*

Substances

  • DNA-Binding Proteins
  • Receptors, Cell Surface
  • Transcription Factors
  • Phosphoserine
  • DNA