Deamidation of human proteins

Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12409-13. doi: 10.1073/pnas.221463198. Epub 2001 Oct 16.

Abstract

Deamidation of asparaginyl and glutaminyl residues causes time-dependent changes in charge and conformation of peptides and proteins. Quantitative and experimentally verified predictive calculations of the deamidation rates of 1,371 asparaginyl residues in a representative collection of 126 human proteins have been performed. These rates suggest that deamidation is a biologically relevant phenomenon in a remarkably large percentage of human proteins.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Asparagine / metabolism
  • Glutamine / metabolism
  • Humans
  • Protein Conformation
  • Proteins / metabolism*

Substances

  • Proteins
  • Glutamine
  • Asparagine