Abstract
A protective mechanism used by cells to adapt to stress of the endoplasmic reticulum (ER) is the induction of members of the glucose-regulated protein (Grp) family. The induction of mammalian Grp proteins in response to ER stress involves a complex network of regulators and novel mechanisms. The elucidation of Grp function and regulation opens up new therapeutic approaches to diseases associated with ER stress and cancer.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Gene Expression Regulation*
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Genetic Therapy
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HSP70 Heat-Shock Proteins / genetics*
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HSP70 Heat-Shock Proteins / metabolism
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Humans
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Immunotherapy
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Membrane Proteins / genetics*
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Membrane Proteins / metabolism
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Neoplasms / metabolism
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Neoplasms / therapy
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Oxidative Stress*
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Promoter Regions, Genetic
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Transcription, Genetic
Substances
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HSP70 Heat-Shock Proteins
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Membrane Proteins
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glucose-regulated proteins