Abstract
We report the cloning, characterization, and chromosomal localization of two novel human members of the bicarbonate transporter superfamily, BTR1 (Bicarbonate Transporter Related protein-1) and AE4 (Anion Exchange protein 4). BTR1 is a novel mammalian protein. The BTR1 gene maps to chromosome 20p12 and encodes a 100 kDa protein predominantly expressed in the kidney, salivary glands, testis, thyroid glands, and trachea. The AE4 gene maps to chromosome 5q23-31 and encodes a 104 kDa protein expressed mainly in the kidney. Human AE4 shares 84% identity with the recently reported rabbit AE4, a sodium independent, Cl(-)/HCO(-)(3) exchanger located on the apical membrane of beta-intercalated kidney cells.
Copyright 2001 Academic Press.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Motifs / genetics
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Anion Transport Proteins*
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Antiporters / genetics*
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Antiporters / metabolism
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Bicarbonates / metabolism
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Cell-Free System
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Chloride-Bicarbonate Antiporters*
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Chromosomes, Human, Pair 20 / genetics
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Chromosomes, Human, Pair 5 / genetics
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Cloning, Molecular
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Glycosylation
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Humans
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Ion Pumps / genetics
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Ion Pumps / metabolism
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Kidney / metabolism*
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Molecular Sequence Data
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Multigene Family
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Organ Specificity
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Physical Chromosome Mapping
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Protein Biosynthesis
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Sequence Homology, Amino Acid
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Sodium-Bicarbonate Symporters
Substances
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Anion Transport Proteins
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Antiporters
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Bicarbonates
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Chloride-Bicarbonate Antiporters
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Ion Pumps
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SLC4A11 protein, human
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SLC4A9 protein, human
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Sodium-Bicarbonate Symporters
Associated data
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GENBANK/AF336127
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GENBANK/AF336237