Isolation and structures of haterumadioxins A and B, cytotoxic endoperoxides from the Okinawan sponge Plakortis lita

N Takada; M Watanabe; A Yamada; K Suenaga; K Yamada; K Ueda; D Uemura

doi:10.1021/np0003490

Isolation and structures of haterumadioxins A and B, cytotoxic endoperoxides from the Okinawan sponge Plakortis lita

J Nat Prod. 2001 Mar;64(3):356-9. doi: 10.1021/np0003490.

Authors

N Takada¹, M Watanabe, A Yamada, K Suenaga, K Yamada, K Ueda, D Uemura

Affiliation

¹ Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa, Nagoya 464-8602, Japan.

PMID: 11277756
DOI: 10.1021/np0003490

Abstract

Cytotoxic endoperoxides, haterumadioxins A (1) and B (2), were isolated from the Okinawan sponge Plakortis lita. Their structures were determined by spectroscopic analysis. The absolute stereostructure of 1 was determined by degradation reactions and the modified Mosher's method. Haterumadioxins showed significant cytotoxicity against 38 human cancer cell lines.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / chemistry
Antineoplastic Agents / isolation & purification*
Antineoplastic Agents / pharmacology
Dioxanes / chemistry
Dioxanes / isolation & purification*
Dioxanes / pharmacology
Drug Screening Assays, Antitumor
Leukemia P388
Magnetic Resonance Spectroscopy
Molecular Structure
Porifera / chemistry*
Tumor Cells, Cultured

Substances

Antineoplastic Agents
Dioxanes
haterumadioxin A
haterumadioxin B