Abstract
For many years now, it has been known that Ca2+ is an important signaling molecule in the cytosol of the cell, but emerging evidence suggests that Ca2+ might also play a signaling role in the endoplasmic reticulum. For example, agonist-induced fluctuations in free Ca2+ concentration in the endoplasmic reticulum can affect many functions of the endoplasmic reticulum, including protein synthesis and modification, and interchaperone interactions.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Amino Acid Sequence
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Animals
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Calcium / metabolism*
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Calcium Signaling / physiology*
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Calcium-Binding Proteins / chemistry
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Calcium-Binding Proteins / metabolism
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Calreticulin
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Endoplasmic Reticulum / enzymology
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Endoplasmic Reticulum / metabolism*
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Heat-Shock Proteins / metabolism
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Isomerases / metabolism
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Molecular Chaperones / chemistry
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Molecular Chaperones / metabolism
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Protein Disulfide-Isomerases / metabolism
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Ribonucleoproteins / chemistry
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Ribonucleoproteins / metabolism
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Signal Transduction
Substances
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Calcium-Binding Proteins
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Calreticulin
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Heat-Shock Proteins
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Molecular Chaperones
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Ribonucleoproteins
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Isomerases
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Protein Disulfide-Isomerases
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Calcium