Expression of Chx10 and Chx10-1 in the developing chicken retina

Mech Dev. 2000 Feb;90(2):293-7. doi: 10.1016/s0925-4773(99)00251-8.

Abstract

We have isolated full-length cDNAs of chick Chx10 and Chx10-1, two members of the paired type homeobox/CVC gene family. A comparison of sequences suggests that Chx10 is closely related to Alx/Vsx-2 and Vsx-2 of zebrafish and goldfish, respectively; while Chx10-1 is closely related to Vsx-1 of zebrafish and goldfish. Chx10 and Chx10-1 are expressed in the early retinal neuroepithelium, but not in the pigment epithelium and lens. The expression of Chx10 is present in most retinal neuroblasts, while Chx10-1 exhibits a novel pattern along the nasotemporal border. In the differentiating retina, both Chx10 and Chx10-1 are restricted to bipolar cells and are maintained at a low level in bipolar cells of the mature retina.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Avian Proteins*
  • Chick Embryo
  • Eye Proteins / genetics
  • Gene Expression
  • Homeodomain Proteins / genetics*
  • Molecular Sequence Data
  • Retina / embryology*
  • Sequence Homology, Amino Acid
  • Tissue Distribution
  • Transcription Factors / genetics*

Substances

  • Avian Proteins
  • Eye Proteins
  • Homeodomain Proteins
  • Transcription Factors

Associated data

  • GENBANK/AF178670
  • GENBANK/AF178671