Abstract
Mutations affecting myosin-VIIa are known to cause deafness and blindness in human Usher syndrome. Mutation of the Dictyostelium myosin-VII gene has now revealed a role for this unconventional myosin in phagocytic events, providing a possible clue to the role of mammalian myosin-VIIa in the inner ear and retina.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Actins / physiology
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Animals
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Blindness / congenital
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Blindness / genetics
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Cytoskeleton / physiology
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Deafness / congenital
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Deafness / genetics
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Dictyostelium / genetics
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Dictyostelium / physiology
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Dyneins
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Eye Proteins / genetics
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Eye Proteins / physiology
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Gene Targeting
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Hair Cells, Auditory / metabolism
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Humans
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Mice
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Mice, Neurologic Mutants
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Molecular Motor Proteins* / genetics
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Myosin VIIa
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Myosins / chemistry
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Myosins / genetics
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Myosins / physiology*
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Nerve Tissue Proteins / genetics
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Nerve Tissue Proteins / physiology
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Particle Size
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Phagocytosis / physiology*
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Pigment Epithelium of Eye / metabolism
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Protozoan Proteins / genetics
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Protozoan Proteins / physiology
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Species Specificity
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Syndrome
Substances
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Actins
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Eye Proteins
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MYO7A protein, human
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Molecular Motor Proteins
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Myo7a protein, mouse
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Myosin VIIa
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Nerve Tissue Proteins
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Protozoan Proteins
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Myosins
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Dyneins