Ceramide-induced apoptosis occurs independently of caspases and is decreased by leupeptin

Cell Death Differ. 1999 Aug;6(8):788-95. doi: 10.1038/sj.cdd.4400552.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Apoptosis*
  • Caspase 3
  • Caspase Inhibitors
  • Caspases / metabolism*
  • Cysteine Proteinase Inhibitors / metabolism*
  • Cysteine Proteinase Inhibitors / pharmacology
  • Enzyme Activation
  • Enzyme Inhibitors / metabolism*
  • Enzyme Inhibitors / pharmacology
  • Female
  • Humans
  • Leupeptins / metabolism*
  • Leupeptins / pharmacology
  • Necrosis
  • Sphingosine / analogs & derivatives*
  • Sphingosine / metabolism
  • Sphingosine / pharmacology
  • Tumor Cells, Cultured
  • U937 Cells
  • fas Receptor / metabolism

Substances

  • Caspase Inhibitors
  • Cysteine Proteinase Inhibitors
  • Enzyme Inhibitors
  • Leupeptins
  • N-acetylsphingosine
  • fas Receptor
  • CASP3 protein, human
  • Caspase 3
  • Caspases
  • leupeptin
  • Sphingosine