In vitro production of IFN-gamma correlates with CA repeat polymorphism in the human IFN-gamma gene

V Pravica; A Asderakis; C Perrey; A Hajeer; P J Sinnott; I V Hutchinson

doi:10.1046/j.1365-2370.1999.00122.x

In vitro production of IFN-gamma correlates with CA repeat polymorphism in the human IFN-gamma gene

Eur J Immunogenet. 1999 Feb;26(1):1-3. doi: 10.1046/j.1365-2370.1999.00122.x.

Authors

V Pravica¹, A Asderakis, C Perrey, A Hajeer, P J Sinnott, I V Hutchinson

Affiliation

¹ School of Biological Sciences, University of Manchester, UK.

PMID: 10068907
DOI: 10.1046/j.1365-2370.1999.00122.x

Abstract

The DNA sequence of the human IFN-gamma gene shows the presence of a variable-length CA repeat in the first intron of the gene. We investigated the allele distribution of this microsatellite region in 164 unrelated healthy individuals, and the association with interferon-gamma (IFN-gamma) production. In vitro production of IFN-gamma showed a significant correlation with the presence of allele #2.

MeSH terms

Alleles
Chromosomes, Human, Pair 12 / genetics
Dinucleotide Repeats / genetics*
Enzyme-Linked Immunosorbent Assay
Genetic Testing
Genotype
Humans
Interferon-gamma / genetics*
Molecular Sequence Data
Polymorphism, Genetic

Substances

Interferon-gamma

Associated data

GENBANK/AF031844